Center for Basic and Translational Research on Disorders of the Digestive System
The Rockefeller University Center for Basic and Translational Research on Disorders of the Digestive System (CDDS) was established in 2012 with a $15 million gift from The Leona M. and Harry B. Helmsley Charitable Trust to fund research into digestive disorders including metabolic diseases, cancers, and infections. In 2015, the Helmsley Trust generously renewed its support for the CDDS with a second three-year grant of $15 million. The Center supports interdisciplinary research and fosters collaborations among some 20 Rockefeller labs that study biological processes related to the digestive system. The Center also supports clinically oriented studies centered in The Rockefeller University Hospital.
Conditions under study in the Center include inflammatory bowel disorders such as Crohn’s disease and colitis; obesity and metabolic disease; celiac disease; disorders of bowel motility, including scleroderma; and several malignancies, such as gastrointestinal stromal tumors and colorectal, liver, and pancreatic cancer.
In addition to including laboratories working in the fields of immunology, microbiology, cancer biology, and metabolic disease, the Center provides support for the training of Ph.D. students, postdoctoral researchers, and physician-scientists. The Center also provides seed funding in the form of Pilot Project Grants for early phase projects involving promising new paths to discovery. The Center sponsors seminars and symposia, and provides support for the purchase of essential shared equipment.
Contact
Barry S. Coller, M.D., Director
Center for Basic and Translational Research
on Disorders of the Digestive System
212-327-7490
cdds@rockefeller.edu
Liver metastases from human colon cancer. Nodules represent distinct liver metastases with varying degrees of central necrosis.
Low power micrograph of the normal colonic mucosa showing crypts lined by epithelial cells protruding from the colonic surface.
Peyer's patch from a Th Cre x Rosa26 TdTomato mouse, B220 (green), CD11c (blue).
Proximal jejunum from a C57BL/6 mouse, B220 (green), CD11c (blue).
Duodenum from a C57BL/6 mouse, B220 (green), CD11c (blue).
Colonic isolated lymphoid follicle from a Serotonin transporter Cre x Rosa26 TdTomato mouse. B220 (green), Serotonin transporter positive cells (red), CD11c (blue).
Small intestine from Rag-/- mouse following transfer of Thpok expressing CD4 positive cells (green), CD4 positive, Thpok negative cells (red).
Small intestine from a CD11cYFP transgenic mouse which expresses CD11c constitutively (green).
C57BL/6 proximal jejunum stained with anti-beta III Tubulin (green), B220 (red), CD11c (blue).
